Cell Division: Kinetochores SKAdaddle
نویسندگان
چکیده
Accurate chromosome segregation during cell division requires that kinetochores couple microtubule dynamics to chromosome movement. New research reveals that the kinetochore-associated Ska1 complex hangs on to depolymerizing microtubules and brings some important friends along for the ride.
منابع مشابه
Cell Division: Molecular Pathways for KMN Kinetochore Recruitment
Robust but dynamic attachment between kinetochores and spindle microtubules is an essential prerequisite for accurate chromosome segregation and for preventing aneuploidy. A pair of recent studies has shed light on the details of how the molecular machinery that orchestrates these attachments is recruited to mitotic kinetochores.
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Kinetochores are specialized protein complexes assembled on centromeric DNA that connect to spindle microtubules and mediate proper chromosome segregation during cell division. Recent results have implicated specific kinetochore proteins in microtubule attachment.
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During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint ...
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The mitotic cyclins promote cell division by binding and activating cyclin-dependent kinases (CDKs). Each cyclin has a unique pattern of subcellular localization that plays a vital role in regulating cell division. During mitosis, cyclin B1 is known to localize to centrosomes, microtubules, and chromatin. To determine the mechanisms of cyclin B1 localization in M phase, we imaged full-length an...
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Kinetochores direct attachment of chromosomes to microtubules of the mitotic spindle during cell division. Three recent studies in Cell, including one in this issue, reveal important new roles for two kinetochore protein complexes-Ndc80 and INCENP-Survivin-in establishing the correct attachment of chromosomes to spindle microtubules (Cheeseman et al., 2006, DeLuca et al., 2006 and Sandall et al...
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ورودعنوان ژورنال:
- Current Biology
دوره 23 شماره
صفحات -
تاریخ انتشار 2013